The biology debate A considerable body of research points to a biological basis for sexual orientation "What did I do wrong?" Many lesbians and gay men have faced this difficult question when coming out to their parents. The answer has usually been something along the lines of "Nothing," or "I've always known I was this way," or "I think I was born gay." Unfortunately, there has never been hard scientific proof to back up these assertions. But as Oscar Wilde once observed, science is always making wonderful improvements on things. There is mounting evidence that sexual orientation is the complex effect of processes that begin well before birth. The significance of research into the causes of sexual orientation may be profound. On the one hand, scientific research has conclusively put to rest the harmful myth that homosexuality is a sexual "preference" or lifestyle choice. But it also raises the spectre of eugenic cleansing, or weeding out the "unfit" through prenatal genetic testing. We must be very careful about how we use the knowledge we gain from research. What we know about sexual orientation remains fairly limited, and draws on research in a number of fields: psychiatry, the anatomy of the brain, hormonal activity, and genetics. "Curing" homosexuality Psychiatrists first turned their attention to homosexuality decades ago. They assumed that what had been treated historically as a sinful or criminal activity was instead a form of mental illness. Gay historians have documented plenty of shocking cases of individuals "cured" of their homosexuality through such treatments as lobotomies, castration and crude electric shock therapies. What researchers were unable to do is demonstrate either that an individual could choose to be homosexual, or that there was a psychological profile that was consistently and demonstrably homosexual. In short, there was nothing empirically observable to suggest a fundamental psychological difference between homosexuals and heterosexuals. More recently, studies of the anatomy of the brain have led to the suggestion that certain regions of the brain vary between males and females and, moreover, that particular regions may also vary with sexual orientation, at least among males. The evidence draws on studies of rat brains, but is based primarily on a 1991 study of brain tissues taken during autopsies from individuals who died in New York and California hospitals. The evidence to date is suggestive, not conclusive. And a firm link between anatomy and sexual orientation still doesn't answer the tantalizing question, "Why?" Hormonal activity may suggest answers. Other studies of rats have observed remarkable changes in sexual behaviour in both castrated males injected with estrogen and females injected with testosterone. Some scientists suggest that the hormonal effects that count are those that take place in the womb. One hint: an unusually high proportion of women identifying themselves as lesbian or bisexual appear to have been exposed prenatally to much higher levels of male hormones than usual. A gay gene? The high incidence of shared sexual orientation among identical twins, who share the same genetic code, has encouraged geneticists to explore the possibility that the human genetic code includes instructions for gay traits, including non-sexual behaviour. Genetic studies of generations of fruit flies have demonstrated harmless evolutionary changes to genes that have led to consistent, complex behaviour patterns that may be analogous to human homosexual activity. As with the rat studies, the analogy is surely oversimplified, and if there is a genetic basis for homosexuality it is probably a complex combination of effects from a number of genes. Preliminary studies of human samples also point to genetic influence on sexual orientation. These studies in different scientific fields are clearly pointing towards the conclusion that there is a biological basis for sexual orientation. What we don't yet know is what effect (if any) one's childhood environment may have on adult sexual behaviour. But the progress of research does suggest that in a few years, we'll be able to point to the latest biology textbook to explain why we are what we are. ...scientific research has conclusively put to rest the harmful myth that homosexuality is a sexual "preference" or lifestyle choice. 682 words