TI "Clinical Manifestations of AIDS in the Era of Pneumocystic Prophylaxis" AU Hoover, Donald R. et al. SO New England Journal of Medicine (12/23/93) Vol. 329, No. 26, P. 1922 AB Pneumocystic carinii pneumonia once occurred in as much as 75 percent of the AIDS population. Prophylactic regimens against the infection are not known to alter HIV or immune function, nor do they protect against other AIDS-related conditions--except toxoplasmosis--or directly alter the patho-psychologic processes leading to other AIDS-related illnesses. By preventing or delaying death from p. carinii pneumonia, however, prophylaxis does shift the clinical manifestations of HIV infection from p. carinii pneumonia to illnesses that occur when immune function is more suppressed. Researchers must now determine what other AIDS-related conditions should be targeted for further prophylaxis and treatment. Hoover et al., therefore, conducted a study of 844 men with AIDS. The results indicated that prophylaxis could delay the onset of the first AIDS-related illness by six months to a year. The study also concluded that only four--myobacterium avium, esophagus candidiasis, wasting syndrome, and cytomegalovirus disease--out of thirteen AIDS-related conditions were observed to surface more often in patients who received prophylaxis against p. carinii pneumonia than in those who did not. Copyright (c) 1993 - Information, Inc., Bethesda, MD. This information is provided by the Centers for Disease Control & Prevention (CDC), National AIDS Clearinghouse as a public service. Non-profit reproduction is encouraged. * Origin: AEGIS/San Juan Capistrano 714.248.2836 (CASAN) (1:103/927) * Provided as a service of THE BACKROOM - NYC * 718-951-8256